RNA Polymerase III: A Key Enzyme in Gene Expression and DNA Replication

Target Name: DNA-directed RNA polymerase III

NCBI ID: P18167

DNA-directed RNA polymerase III

Other Name(s): RNA Polymerase III | Pol-III | RNA polymerase III (Pol III) complex | DNA-dependent RNA polymerase III | Pol III

RNA Polymerase III: A Key Enzyme in Gene Expression and DNA Replication

DNA-directed RNA polymerase III (RNA Polymerase III) is a enzyme that plays a crucial role in gene expression and DNA replication. It is a key enzyme in the polymerase chain, which is responsible for creating new DNA strands based on the template that is passed to it. RNA Polymerase III is also involved in the regulation of gene expression, and is a potential drug target for several diseases.

RNA Polymerase III is a protein that consists of 13 subunits that are held together by a disulfide bond. It has a molecular weight of 176 kDa and a pre-functional size of 19.8 kDa. RNA Polymerase III has a unique mechanism of action that allows it to only incorporate DNA sequences that are the first 30 nucleotides of the template. This is accomplished by a specific base called hypoxanthocyanine, which acts as a chain terminator by preventing the DNA from being cut off.

RNA Polymerase III is responsible for creating the primary transcript of a gene. It is a highly specific enzyme that only recognizes and creates a specific sequence of DNA. The sequence that it creates is dependent on the template DNA and the properties of the cell. RNA Polymerase III is able to create long, highly specific transcripts that are free of introns and exons.

RNA Polymerase III is also involved in the regulation of gene expression. It is able to interact with several different transcription factors, including RNA factors and DNA factors. These factors are able to bind to specific locations on the DNA template and cause RNA Polymerase III to either activate or repress gene expression. This allows RNA Polymerase III to be a powerful tool for the study of gene function and the regulation of gene expression.

RNA Polymerase III is also a potential drug target for several diseases. For example, it is has been shown to be involved in the development of certain types of cancer, such as breast cancer. It is also involved in the regulation of the immune system, which is important for fighting off infections and diseases. Additionally, RNA Polymerase III is involved in the regulation of cell division, which is important for the growth and development of tissues and organs.

In conclusion, DNA-directed RNA polymerase III is a protein that plays a crucial role in gene expression and DNA replication. It is a key enzyme in the polymerase chain and is involved in the regulation of gene expression. RNA Polymerase III is also a potential drug target for several diseases and has been shown to be involved in the development of certain types of cancer, the regulation of the immune system, and the regulation of cell division. Further research is needed to fully understand the role of RNA Polymerase III in disease and to develop new treatments.

Protein Name: DNA-directed RNA Polymerase III

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